Antibiotics: Challenges, Mechanisms, Opportunities. Christopher Walsh, Timothy Wencewicz

Antibiotics: Challenges, Mechanisms, Opportunities


Antibiotics.Challenges.Mechanisms.Opportunities.pdf
ISBN: 9781555819309 | 448 pages | 12 Mb


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Antibiotics: Challenges, Mechanisms, Opportunities Christopher Walsh, Timothy Wencewicz
Publisher: ASM Press



Antibiotic discovery is not very fashionable these days, and yet resistance has are already underlying resistance mechanisms — hardly the pharmaceutical There is still a great need, and commercial opportunity, for novel antibacterials. Antibiotics: Challenges, Mechanisms, Opportunities focuses on antibiotics as small organic molecules, from both natural and synthetic sources. Most common mechanism of β-lactam resistance is due to enzymatic hydrolysis of the β-lactam ring. Biological fitness costs: Most antibiotic resistance mechanisms carry a cost to the bacteria .. Antibiotics: Challenges, Mechanisms, Opportunities details the contemporary challenges for discovery, optimization, and advancement of new antibiotics. Antibiotics: 51 hours for resistant infections vs 16 hours for susceptible infections. Download Antibiotics: Challenges, Mechanisms, Opportunities Book Here! Resistance R&D with lower opportunity costs and better economies of scale. If resistance to these drugs emerges, awareness of potential mechanisms would enable a more focused approach to detecting mutations in T. Antibiotics: Challenges, Mechanisms, Opportunities focuses on antibiotics as small organic molecules, from both natural and synthetic sourcFes. Antibac- terial R&D has been associated with several challenges that ..





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